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چاپ مقاله اعضای مرکز تحقیقات کودکان

چاپ مقاله

چاپ مقاله اعضای گروه کودکان در مجله ایندکس ISI

Predicting Factors of Atherosclerosis in Children with Beta-Thalassemia Major

Bahram Darbandi, Nasim Ghorbannezhad, Adel Baghersalimi, Shahin Koohmanaee, Afagh Hassanzadeh Rad, Zahra Atrkar Roshan, Saeid Anvari, Setila Dalili, Manijeh Tabrizi
Publication date
2023/1/10
Journal
Iranian Journal of Pediatric Hematology and Oncology
Volume
13
Issue
1
Pages
43-51
Publisher
Iranian Journal of Pediatric Hematology and Oncology
Description
Background: Atherosclerosis is an important cardiovascular disorder in beta-thalassemia major patients. The present study aimed to predict factors of atherosclerosis in children with beta-thalassemia major.
Materials and Methods: This cross-sectional study was conducted on 36 patients with beta-thalassemia major and 36 healthy children as the control group. The carotid intima-media thickness (CAIMT) and osteoprotegerin (OPG) were compared between groups.
Results: The mean age of the patients in the case and control groups were 13.5±3.7 and 13±3.1 years old, respectively. Significant differences in CAIMT in the right (P= 0.001) and left (P= 0.001) arteries were recorded between the two groups. The mean serum OPG in the beta-thalassemia group was significantly higher than the control group (3.9 ng/ml and 1.4 ng/ml, respectively, P= 0.001).
Conclusion: CAIMT is a non-invasive method for diagnosing atherosclerosis. According to the significant difference between groups, serum OPG could be helpful in the diagnosis of early atherosclerosis in beta-thalassemia major.
  • گروه خبری : گروه های مطالب,اخبار مرکز تحقیقات کودکان,pediatrics news,اخبار اختصاصی,اطلاعیه ها,رویدادها,گزارش های تصویری
  • کد خبر : 102901
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