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چاپ مقاله اعضای مرکز تحقیقات کودکان 1402آبان

چاپ مقاله اعضای مرکز تحقیقات کودکان ابان

چاپ مقاله در plos one

Authors
Marjaneh Zarkesh, Sadroddin Mahdipour, Safoora Aghili, Atefeh Jafari, Seyyedeh Azadeh Hoseini Nouri, Afagh Hassanzadeh Rad, Maryam Ghalandari, Manijeh Tabrizi
Publication date
2023/12/12
Journal
Plos one
Volume
18
Issue
12
Pages
e0273516
Publisher
Public Library of Science
Description
Introduction and aims
Phototherapy is the most common treatment modality of neonatal hyperbilirubinemia. We aimed to evaluate the therapeutic effect of oral Ursodeoxycholic Acid (UDCA) on indirect hyperbilirubinemia in term neonates undergoing phototherapy.
Materials and methods
This randomized controlled clinical trial was performed on 106 full-term neonates with jaundice who were admitted to the neonatal ward of 17 Shahrivar Hospital in Rasht, Iran. The neonates were randomly assigned to two groups of intervention (10 mg/kg UDCA+phototherapy) and control (phototherapy alone). Total serum bilirubin (TSB) was measured at the time of admission, during first 12, 24, and 48 hours after admission and at the time of discharge. The duration of hospitalization and side effects were also assessed in both groups. IBM SPSS Statistics for Windows, version 20 was used to analyze the data.
Results
Results showed that in the intervention group, 28 (52.8%) of neonates were boys with the mean age of 5.1±1.25 days. While, in the control group 29 (54.7%) of them were boys with the mean age of 5.19±2.26 days. Bilirubin levels in both groups decreased significantly after hospitalization (at 12, 24 and 48 hours) (P <0.001). The mean of bilirubin at 12, 24 and 48 hours in the intervention and control groups were 17.1, 13.2, 10.2 mg / dl and 17.1, 14.2 and 11.3 mg / dl, respectively. At the time of discharge, TSB in the former compared to the latter group was significantly reduced (7.74± 1.39 vs. 8.67±1.35) (P = 0.001). In addition, the duration of hospitalization was considerably shorter in the intervention compared to the control group (P = 0.038) and …
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